Osteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous skeletal
dysplasia characterized by bone fragility, growth deficiency, and skeletal deformity …

Osteogenesis Imperfecta (OI) is a genetic disorder characterized by various clinical features
including bone deformities, low bone mass, brittle bones, and connective tissue …

Pancreatic ductal adenocarcinoma (PDAC) has a collagen-rich dense extracellular matrix
(ECM) that promotes malignancy of cancer cells and presents a barrier for drug delivery …

Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a
number of systemic hormones and transcription factors are known to regulate proliferation …

Abstract Bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases, here called BTPs,
include the proteases originally identified for their roles in the C-terminal maturation of …

Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not
the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) …

Bone secretory proteins, termed osteokines, regulate bone metabolism and whole-body
homeostasis. However, fundamental questions as to what the bona fide osteokines and their …

Abstract BMP-1/tolloid-like proteinases (BTPs) are major players in tissue morphogenesis,
growth and repair. They act by promoting the deposition of structural extracellular matrix …

Abstract Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are closely related
TGFβ family members that are often believed to serve similar functions due to their high …

Metalloproteases meprin α and meprin β were recently discovered as procollagen
proteinases, capable of cleaving off the globular C-and N-terminal prodomains of fibrillar …