There has been mounting evidence of a causal role for telomere dysfunction in a number of
degenerative disorders. Their manifestations encompass common disease states such as …

This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

This volume and its companion, Volume 350, are specifically designed to meet the needs of
graduate students and postdoctoral students as well as researchers, by providing all the up …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
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Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic
chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich …

The intent of this review is to describe what is known and unknown about telomerase in
somatic cells of the human organism. First, we consider the telomerase enzyme. Human …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Telomeres, the natural ends of linear chromosomes, comprise repeat-sequence DNA and
associated proteins. Replication of telomeres allows continued proliferation of human stem …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …