Recent years have witnessed tremendous growth in the epidermal growth factor (EGF)
family of peptide growth factors and the ErbB family of tyrosine kinases, the receptors for …

Studying the formation of the embryonic axes in mammals poses a special problem because
patterning of the embryo itself is a relatively late event in development. In the mouse, explicit …

Mitogen-activated protein kinase (MAP kinase) cascades transmit and amplify signals
involved in cell proliferation as well as cell death. These signal transduction pathways serve …

The anterior–posterior axis of the mouse embryo is established by two distinct organizing
centres in the anterior visceral endoderm and the distal primitive streak,,,,,,. These …

Several key growth factors, cytokines, and proto-oncogenes transduce their growth-and
differentiation-promoting signals through the mitogen-activated protein kinase or …

The zebrafish one-eyed pinhead (oep) mutation disrupts embryonic development, resulting
in cyclopia and defects in endoderm, prechordal plate, and ventral neuroectoderm …

Introduction 3. The EGF-related growth factors 4. The EGF-CFC family 5. The erbB receptor
family 6. EGF-like growth factors in cell proliferation and oncogenesis 6.1 The EGF-like …

During organogenesis, the endoderm forms the epithelial lining of the primitive gut tube from
which the alimentary canal and associated organs, such as the liver and pancreas, develop …

Cripto is a developmental oncoprotein that signals via mitogen-activated protein kinase
(MAPK)/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase …

It is increasingly evident that genes known to perform critical roles during early
embryogenesis, particularly during stem cell renewal, pluripotentiality and survival, are also …