Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Systemic and pulmonary circulations constitute a complex organ that serves multiple
important biological functions. Consequently, any pathological processing affecting the …

It is well established that control of vascular morphogenesis and homeostasis is regulated
by vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), Delta-like 4 …

Endothelial cells line all blood vessels, where they coordinate blood vessel formation and
the blood-tissue barrier via regulation of cell-cell junctions. The nucleus also regulates …

Engineering of three-dimensional (3D) tissues is a promising approach for restoring
diseased or dysfunctional myocardium with a functional replacement. However, a major …

Endothelial cells (ECs) respond to shear stress by aligning in the direction of flow. However,
how ECs respond to flow in complex in vivo environments is less clear. Here we describe an …

In vivo, cells of the vascular system are subjected to various mechanical stimuli and have
demonstrated the ability to adapt their behavior via mechanotransduction. Recent advances …

The endothelial cells (ECs) that line the inner layer of blood vessels are responsible for
maintaining vascular homeostasis under physiological conditions. In the presence of …

Endothelial senescence entails alterations of the healthy cell phenotype, which accumulate
over time and contribute to cardiovascular disease. Mechanical aspects regulating cell …

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta
(TGFβ) superfamily of cytokines. While some ligand members are potent inducers of …