Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …

Microglia are the resident macrophage population of the central nervous system (CNS).
Adequate microglial function is crucial for a healthy CNS. Microglia are not only the first …

Across the animal kingdom, gastrulation represents a key developmental event during which
embryonic pluripotent cells diversify into lineage-specific precursors that will generate the …

Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …

Hematopoiesis–the process by which blood cells are formed–has been studied intensely for
over a century using a variety of model systems. There is conservation of the overall …

Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in
two distinct flavors-primitive and definitive. Definitive RBCs in mammals circulate as smaller …

Through their oxygen delivery function, red blood cells are pivotal to the healthy existence of
all vertebrate organisms. These cells are required during all stages of life—embryonic, fetal …

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

In mammals, specification of the three major germ layers occurs during gastrulation, when
cells ingressing through the primitive streak differentiate into the precursor cells of major …