[HTML][HTML] The role of T-cells in head and neck squamous cell carcinoma: from immunity to immunotherapy

MPS Damasio, CS Nascimento, LM Andrade… - Frontiers in …, 2022 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) encompass a group of complex entities
of tumours affecting the aerodigestive upper tract. The main risk factors are strongly related …

The mouse oral carcinoma (MOC) model: a 10-year retrospective on model development and head and neck cancer investigations

M Kono, S Saito, AM Egloff, CT Allen, R Uppaluri - Oral oncology, 2022 - Elsevier
Preclinical models of cancer have long been paramount to understanding tumor
development and advancing the treatment of cancer. Creating preclinical models that mimic …

[HTML][HTML] HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING

X Luo, CR Donnelly, W Gong, BR Heath… - The Journal of …, 2020 - Am Soc Clin Investig
The incidence of human papillomavirus–positive (HPV+) head and neck squamous cell
carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase …

HPVTIMER: A shiny web application for tumor immune estimation in human papillomavirus‐associated cancers

L Liu, Y Xie, H Yang, A Lin, M Dong, H Wang, C Zhang… - Imeta, 2023 - Wiley Online Library
The tumor immune microenvironment (TIME) is closely associated with tumor formation,
particularly linked to the human papillomavirus (HPV), and regulates tumor initiation …

[HTML][HTML] The promise of Immuno-oncology: implications for defining the value of cancer treatment

HL Kaufman, MB Atkins, P Subedi, J Wu… - … for immunotherapy of …, 2019 - Springer
The rapid development of immuno-oncology (IO) therapies for multiple types of cancer has
transformed the cancer treatment landscape and brightened the long-term outlook for many …

[HTML][HTML] Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition

JM Newton, A Hanoteau, HC Liu, A Gaspero… - … for immunotherapy of …, 2019 - Springer
Abstract Background Immune checkpoint inhibitors (ICIs) for solid tumors, including those
targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 …

Immunology‐guided biomaterial design for mucosal cancer vaccines

S Ferber, RJ Gonzalez, AM Cryer… - Advanced …, 2020 - Wiley Online Library
Cancer of mucosal tissues is a major cause of worldwide mortality for which only palliative
treatments are available for patients with late‐stage disease. Engineered cancer vaccines …

[HTML][HTML] The role of different immunocompetent cell populations in the pathogenesis of head and neck cancer—regulatory mechanisms of pro-and anti-cancer activity …

K Starska-Kowarska - Cancers, 2023 - mdpi.com
Simple Summary According to the latest GLOBOCAN data, head and neck squamous cell
carcinoma (HNSCC) represents the sixth most prevalent human malignancy. Recent studies …

[HTML][HTML] Up-regulation of hypoxia-inducible factor antisense as a novel approach to treat ovarian cancer

T Lu, J Tang, B Shrestha, BR Heath, L Hong, YL Lei… - Theranostics, 2020 - ncbi.nlm.nih.gov
Ovarian cancer (OC) is estimated to kill~ 14,000 women in the United States in 2019.
Current chemotherapies to treat OC initially show therapeutic efficacy but frequently drug …

Drug-mimicking nanofibrous peptide hydrogel for inhibition of inducible nitric oxide synthase

DG Leach, JM Newton, MA Florez… - ACS biomaterials …, 2019 - ACS Publications
In this work, we develop a drug-mimicking nanofibrous peptide hydrogel that shows long-
term bioactivity comparable to a small-molecule inhibitor of inducible nitric oxide synthase …