Abstract Intracellular calcium (Ca 2+) is an essential second messenger in eukaryotic cells
regulating numerous cellular functions such as contraction, secretion, immunity, growth, and …

Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …

The mammalian exclusive Orai3 channel participates in the generation and/or modulation of
two independent Ca2+ currents, the store-operated current, Icrac, involving functional …

Emerging evidence indicates that intracellular calcium (Ca2+) levels and their regulatory
proteins play essential roles in normal stem cell proliferation and differentiation. Cancer …

Ion channels, as functional molecules that regulate the flow of ions across cell membranes,
have emerged as a promising target in cancer therapy due to their pivotal roles in cell …

Simple Summary Pancreatic cancer (PC) is one of the most lethal forms of cancers with 5-
year mean survival rate of less than 10%. Most of the PC associated deaths are due to …

Store‐operated Ca2+ entry (SOCE) is a major mechanism for Ca2+ influx in colorectal
cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca2+ …

Acute myeloid leukemia (AML) is a hematological malignancy with a high risk of relapse.
This issue is associated with the development of mechanisms leading to drug resistance that …

All human life starts with a calcium (Ca2+) wave. This ion regulates a plethora of cellular
functions ranging from fertilisation and birth to development and cell death. A sophisticated …

ML-9 elicits a broad spectrum of effects in cells, including inhibition of myosin light chain
kinase, inhibition of store-operated Ca 2+ entry and lysosomotropic actions that result in …