Background Therapeutic hypothermia (TH) is regarded as the most efficacious therapy for
neonatal hypoxic encephalopathy. However, limitations in previous systematic reviews and …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Background Whether hypothermic therapy improves neurodevelopmental outcomes in
newborn infants with asphyxial encephalopathy is uncertain. Methods We performed a …

Preterm neonates are susceptible to perinatal hypoxic-ischemic brain injury, for which no
treatment is available. In a preclinical animal model of hypoxic-ischemic brain injury in ovine …

The contributors to this statement were selected to ensure expertise in all the disciplines
relevant to post–cardiac arrest care. In an attempt to make this document universally …

Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …

AIM OF THE REVIEW: To review the epidemiology, pathophysiology, treatment and
prognostication in relation to the post-cardiac arrest syndrome. METHODS: Relevant articles …

● Unconscious adult patients with spontaneous circulation after out-of-hospital cardiac
arrest should be cooled to 32 C to 34 C for 12 to 24 hours when the initial rhythm was …

Data from large randomized clinical trials indicate that therapeutic hypothermia, using either
selective head cooling or systemic cooling, is an effective therapy for neonatal …

Increasing evidence suggests that induction of mild hypothermia (32–35° C) in the first hours
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …