Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …

abstract Asthma is characterized by chronic airway inflammation, variable airway narrowing,
and sensory nerve irritation, which manifest as wheezing, dyspnea, chest tightness, and …

Cough is a common and troublesome symptom in people with asthma and is often
associated with poorer asthma control and exacerbations. Apart from asthma, other causes …

Chronic cough (CC;≥ 8 weeks in duration) is a common and burdensome feature of
respiratory diseases. The understanding of cough has progressed significantly in recent …

Background Asthma is a heterogeneous disease with variable symptoms, which presents
with cough either as the sole or predominant symptom with or without wheezing. We …

Background: Airway mucus hypersecretion is an important pathophysiological feature of
asthma. MUC5AC and MUC5B are the major secreted polymeric mucins in airways, and …

Background Capsaicin cough sensitivity (C-CS) reflects airway neuronal dysfunction and
may be a significant biomarker of asthma. Although mepolizumab reduces cough in patients …

Background Chronic cough can be triggered by respiratory and non-respiratory tract
illnesses originating mainly from the upper and lower airways, and the GI tract (ie, reflux) …

Cough provocation tests (CPTs) are an objective measurement of the sensitivity of the cough
reflex arc. However, they are not established in clinical practice because a large variability of …

Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory
diseases with high prevalence and mortality that significantly alter the quality of life in …