The discovery of Toll in Drosophila and of the remarkable conservation in pathway
composition and organization catalyzed a transformation in our understanding of innate …

Morphogen gradients provide embryonic tissues with positional information by inducing
target genes at different concentration thresholds and thus at different positions. The Bicoid …

In past years, much attention has focused on the gene networks that regulate early
developmental processes, but less attention has been paid to how multiple networks and …

The Drosophila genome activator Vielfaltig (Vfl), also known as Zelda (Zld), is thought to
prime enhancers for activation by patterning transcription factors (TFs). Such priming is …

Summary Paused RNA polymerase (Pol II) is a pervasive feature of Drosophila embryos and
mammalian stem cells, but its role in development is uncertain. Here, we demonstrate that a …

Zygotic genome activation (ZGA) is a major genome programming event whereby the cells
of the embryo begin to adopt specified fates. Experiments in Drosophila and zebrafish have …

Quantitative studies of embryogenesis require the ability to monitor pattern formation and
morphogenesis in large numbers of embryos, at multiple time points and in diverse genetic …

Connecting the developmental patterning of tissues to the mechanistic control of RNA
polymerase II remains a long-term goal of developmental biology. Many key elements have …

Tissue folding promotes three-dimensional (3D) form during development. In many cases,
folding is associated with myosin accumulation at the apical surface of epithelial cells, as …

Patterning of the dorsal-ventral axis in the early Drosophila embryo depends on the nuclear
distribution of the Dorsal transcription factor. Using live two-photon light-sheet microscopy …