Microtubules (MTs) are essential for many cellular processes including establishment of cell
shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning …

Recent studies have demonstrated that stem cells have attracted much attention due to their
special abilities of proliferation, differentiation and self-renewal, and are of great significance …

Carbendazim derivatives, commonly used as antiparasitic drugs, have shown potential as
anticancer agents due to their ability to induce cell cycle arrest and apoptosis in human …

Background Hepatocellular carcinoma (HCC) is one of the most common malignancies and
tends to have a poor prognosis due to its insidious onset, difficulty in early diagnosis, and …

Brain metastases are common in triple-negative breast cancer (TNBC), suggesting a
complex process of cancer spread. The mechanisms enabling TNBC cell adaptation and …

TRPV1, a polymodal and nonselective cation channel has unique gating mechanisms which
is regulated by supramolecular complexes at the plasma membrane formed with membrane …

Histone deacetylases (HDACs) are the major regulators of the balance of acetylation of
histone and non-histone proteins. In contrast to other HDAC isoforms, HDAC6 is mainly …

In cells, microtubule location, length, and dynamics are regulated by a host of microtubule-
associated proteins and enzymes that read where to bind and act based on the microtubule …

Background Tubulins are highly conserved globular proteins involved in stabilization of
cellular cytoskeletal microtubules during cell cycle. Different isoforms of tubulins are …

Targeted therapies for cancer treatment utilize a range of small-molecule drugs or
monoclonal antibodies to influence cancer cell growth, survival, and spread. For prostate …