Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In
this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine …

Abstract Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the
rhizome of Coptis chinensis Franch., C. deltoidea CY Cheng et Hsiao, or C. teeta Wall …

Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous
medicinal plants and has an array of pharmacological properties. It has been used in …

Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

Autophagy is a phylogenetically conserved mechanism that controls the degradation of
subcellular constituents, including misfolded proteins, and damaged organelles. The …

Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Vascular diseases affecting …

Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

Neurodegenerative diseases (NDs) are characterized by disorders with progressive
deterioration of the structure and/or function of neurons. Genetic mutations can lead to many …