Despite advances in biomedicine, the incidence and the mortality of hepatocellular
carcinoma (HCC) remain high. The majority of HCC cases are diagnosed in later stages …

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …

Hepatocellular cancer (HCC) is a highly treatment-refractory cancer and is also highly
resistant to adverse cellular stress. Although cell behavior can be modulated by noncoding …

Mesoporous silica nanoparticles (MSNs) exhibit the typical characteristics of inorganic
materials that make them promising drug delivery carriers for cancer therapy. Their structural …

Liver disease can alter the disposition of xenobiotics and endogenous substances.
Regulatory agencies such as the Food and Drug Administration and the European …

Hepatocellular carcinoma (HCC) metabolism is redirected to glycolysis to enhance the
production of metabolic compounds employed by cancer cells to produce proteins, lipids …

Simple Summary One-third of the approximately 10 million deaths yearly caused by cancer
worldwide are due to hepatobiliary, pancreatic, and gastrointestinal tumors. One primary …

Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. A
polymer-lipid supported mesoporous silica nanoparticle (PLS-MSNs) is described here to …

The lactate receptor, also known as hydroxycarboxylic acid receptor 1 (HCAR1/GPR81),
plays a vital role in cancer biology. Recently, HCAR1 was reported to enhance metastasis …

For most cancers, the treatment of choice is still chemotherapy despite its severe adverse
effects, systemic toxicity and limited efficacy due to the development of multidrug resistance …