Phosphorylated tau in Alzheimer's disease and other tauopathies

P Rawat, U Sehar, J Bisht, A Selman… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Role of tau protein in Alzheimer's disease: The prime pathological player

S Muralidar, SV Ambi, S Sekaran, D Thirumalai… - International journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Alzheimer's disease

HW Querfurth, FM LaFerla - New England Journal of Medicine, 2010 - Mass Medical Soc
This review of Alzheimer's disease assembles a variety of findings relevant to the
mechanism of the disease and ties them together using the current understanding of the …

Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link

Y Zhang, N Huang, F Yan, H Jin, S Zhou, J Shi… - Behavioural brain …, 2018 - Elsevier
It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM),
and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and …

Inflammasomes in neuroinflammation and changes in brain function: a focused review

G Singhal, EJ Jaehne, F Corrigan, C Toben… - Frontiers in …, 2014 - frontiersin.org
Recent literature has pointed to the existence of inflammasome-mediated inflammatory
pathways in central nervous system (CNS) disorders and associated changes in behavior …

Post-translational modifications of tau protein: implications for Alzheimer's disease

L Martin, X Latypova, F Terro - Neurochemistry international, 2011 - Elsevier
Alzheimer's disease (AD) belongs to a group of neurodegenerative diseases collectively
designated as “tauopathies”, because they are characterized by the aggregation of …

[HTML][HTML] Alzheimer disease

RJ Castellani, RK Rolston, MA Smith - Disease-a-month: DM, 2010 - ncbi.nlm.nih.gov
In 1907, Alois Alzheimer described the case of a 51 year old woman who presented with a
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …

Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease

N Kumar, V Kumar, P Anand, V Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Oxidative stress in Alzheimer disease: a possibility for prevention

DJ Bonda, X Wang, G Perry, A Nunomura, M Tabaton… - …, 2010 - Elsevier
Oxidative stress is at the forefront of Alzheimer disease (AD) research. While its implications
in the characteristic neurodegeneration of AD are vast, the most important aspect is that it …

Involvement of oxidative stress in Alzheimer disease

A Nunomura, RJ Castellani, X Zhu… - … of neuropathology & …, 2006 - academic.oup.com
Genetic and lifestyle-related risk factors for Alzheimer disease (AD) are associated with an
increase in oxidative stress, suggesting that oxidative stress is involved at an early stage of …