[HTML][HTML] Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence
There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …
A Review of In Vitro Drug Release Test Methods for Nano‐Sized Dosage Forms
S D'Souza - Advances in pharmaceutics, 2014 - Wiley Online Library
This review summarizes the methods used to study real‐time (37° C) drug release from
nanoparticulate drug delivery systems and establish an IVIVC. Since no compendial …
nanoparticulate drug delivery systems and establish an IVIVC. Since no compendial …
PBPK models for the prediction of in vivo performance of oral dosage forms
ES Kostewicz, L Aarons, M Bergstrand… - European Journal of …, 2014 - Elsevier
Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …
upon numerous factors including the physicochemical properties of the drug, characteristics …
In vitro dissolution testing strategies for nanoparticulate drug delivery systems: recent developments and challenges
J Shen, DJ Burgess - Drug delivery and translational research, 2013 - Springer
Nanoparticulate systems have emerged as prevalent drug delivery systems over the past
few decades. These delivery systems (such as liposomes, emulsions, nanocrystals, and …
few decades. These delivery systems (such as liposomes, emulsions, nanocrystals, and …
Nanomedicines-tiny particles and big challenges
MRC Marques, Q Choo, M Ashtikar, TC Rocha… - Advanced Drug Delivery …, 2019 - Elsevier
After decades of research, nanotechnology has been used in a broad array of biomedical
products including medical devices, drug products, drug substances, and pharmaceutical …
products including medical devices, drug products, drug substances, and pharmaceutical …
[HTML][HTML] In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives
Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …
Drug delivery strategies for poorly water-soluble drugs: the industrial perspective
P van Hoogevest, X Liu, A Fahr - Expert opinion on drug delivery, 2011 - Taylor & Francis
Introduction: For poorly soluble compounds, a good bioavailability is typically needed to
assess the therapeutic index and the suitability of the compound for technical development …
assess the therapeutic index and the suitability of the compound for technical development …
Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate
The objectives of this study were to characterise three prototype fenofibrate lipid-based
formulations using a range of in vitro tests with differing levels of complexity and to assess …
formulations using a range of in vitro tests with differing levels of complexity and to assess …
Development considerations for nanocrystal drug products
ML Chen, M John, SL Lee, KM Tyner - The AAPS journal, 2017 - Springer
Nanocrystal technology has emerged as a valuable tool for facilitating the delivery of poorly
water-soluble active pharmaceutical ingredients (APIs) and enhancing API bioavailability …
water-soluble active pharmaceutical ingredients (APIs) and enhancing API bioavailability …
Cyclodextrin-water soluble polymer ternary complexes enhance the solubility and dissolution behaviour of poorly soluble drugs. Case example: Itraconazole
T Taupitz, JB Dressman, CM Buchanan… - European Journal of …, 2013 - Elsevier
The aim of the present series of experiments was to improve the solubility and dissolution/
precipitation behaviour of a poorly soluble, weakly basic drug, using itraconazole as a case …
precipitation behaviour of a poorly soluble, weakly basic drug, using itraconazole as a case …