NADPH oxidase in brain injury and neurodegenerative disorders

MW Ma, J Wang, Q Zhang, R Wang… - Molecular …, 2017 - Springer
Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

MA Friese, B Schattling, L Fugger - Nature Reviews Neurology, 2014 - nature.com
Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

MT Fischer, R Sharma, JL Lim, L Haider, JM Frischer… - Brain, 2012 - academic.oup.com
Multiple sclerosis is a chronic inflammatory disease of the central nervous system,
associated with demyelination and neurodegeneration. The mechanisms of tissue injury are …

Association between cigarette smoking and multiple sclerosis: a review

M Rosso, T Chitnis - JAMA neurology, 2020 - jamanetwork.com
Importance Cigarette smoking is a common environmental exposure and addiction, which
has severe health consequences. Smoking is a risk factor for multiple sclerosis (MS); also …

Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D

I Wessels, L Rink - The Journal of nutritional biochemistry, 2020 - Elsevier
A functional immune system is essential for healthy life. This is achieved by the coordinate
activation and interaction of different immune cells. One should be aware that activation of …

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

HM Gao, H Zhou, JS Hong - Trends in pharmacological sciences, 2012 - cell.com
Oxidative stress is a key pathologic factor in neurodegenerative diseases such as Alzheimer
and Parkinson diseases (AD, PD). The failure of free-radical-scavenging antioxidants in …

Oxidative/nitroxidative stress and multiple sclerosis

TO Tobore - Journal of Molecular Neuroscience, 2021 - Springer
Multiple sclerosis (MS) is a multifactorial, central nervous system, immune-mediated disease
characterized by inflammation, demyelination, and neurodegeneration. Evidence suggests a …

Chronic exercise confers neuroprotection in experimental autoimmune encephalomyelitis

WM Pryor, KG Freeman, RD Larson… - Journal of …, 2015 - Wiley Online Library
Multiple sclerosis (MS) is an autoimmune disease that affects the CNS, resulting in
accumulated loss of cognitive, sensory, and motor function. This study evaluates the …

Inflammation, iron, energy failure, and oxidative stress in the pathogenesis of multiple sclerosis

L Haider - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous
system. Different trigger pathologies have been suggested by the primary cytodegenerative …

Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury

SJ Cooney, SL Bermudez-Sabogal… - Journal of …, 2013 - Springer
Background Brain injury results in an increase in the activity of the reactive oxygen species
generating NADPH oxidase (NOX) enzymes. Preliminary studies have shown that NOX2 …