Rheumatoid arthritis (RA), an autoimmune disease that affects∼ 1% of the human
population, is driven by autoantibodies that target modified self-epitopes, whereas∼ 11% of …

Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire
nutrients, communicate with other species, defend against biological and chemical agents …

A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of
modern germ theory. Recent studies implicate mucosal surfaces as sites of disease …

Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products
are attractive for genome-driven discovery and re-engineering, but limitations in …

Observations from numerous clinical, epidemiological and serological studies link
periodontitis with severity and progression of rheumatoid arthritis. The strong association is …

The anaerobic Gram-negative bacterium Porphyromonas gingivalis is considered the
keystone of periodontitis diseases, a set of inflammatory conditions that affects the tissues …

Background Cancer impacts millions of lives globally each year, with approximately 10
million cancer-related deaths recorded worldwide in 2020. Mounting research has …

The type 9 secretion system (T9SS) is the protein export pathway of bacteria of the Gram-
negative Fibrobacteres–Chlorobi–Bacteroidetes superphylum and is an essential …

Periodontitis is a chronic inflammatory condition that destroys the tooth‐supporting tissues
and eventually leads to tooth loss. As one of the most prevalent oral conditions, periodontitis …

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by
immune-mediated damage of synovial joints and antibodies to citrullinated antigens …