Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

The transport of mRNAs to distal subcellular compartments is an important component of
spatial gene expression control in neurons. However, the mechanisms that control mRNA …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Decades of work have demonstrated that messenger RNAs (mRNAs) are localized and
translated within neuronal dendrites and axons to provide proteins for remodeling and …

In eukaryotic cells, proteins are targeted to their final subcellular locations with precise
timing. A key underlying mechanism is the active transport of cognate mRNAs, which in …

Essentially all cells contain a variety of spatially restricted regions that are important for
carrying out specialized functions. Often, these regions contain specialized transcriptomes …