Anomalous transport in the crowded world of biological cells

F Höfling, T Franosch - Reports on Progress in Physics, 2013 - iopscience.iop.org
A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …

Dynamic organizing principles of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolson's fluid …

A Kusumi, TK Fujiwara, R Chadda, M Xie… - Annual review of cell …, 2012 - annualreviews.org
The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …

Hierarchical mesoscale domain organization of the plasma membrane

A Kusumi, KGN Suzuki, RS Kasai, K Ritchie… - Trends in biochemical …, 2011 - cell.com
Based on recent single-molecule imaging results in the living cell plasma membrane, we
propose a hierarchical architecture of three-tiered mesoscale (2–300nm) domains to …

Nonergodicity mimics inhomogeneity in single particle tracking

A Lubelski, IM Sokolov, J Klafter - Physical review letters, 2008 - APS
Most statistical theories of anomalous diffusion rely on ensemble-averaged quantities such
as the mean squared displacement. Single molecule tracking measurements require …

Advances in image correlation spectroscopy: measuring number densities, aggregation states, and dynamics of fluorescently labeled macromolecules in cells

DL Kolin, PW Wiseman - Cell biochemistry and biophysics, 2007 - Springer
A brief historical outline of fluorescence fluctuation correlation techniques is presented,
followed by an in-depth review of the theory and development of image correlation …

[HTML][HTML] Guidelines for the fitting of anomalous diffusion mean square displacement graphs from single particle tracking experiments

E Kepten, A Weron, G Sikora, K Burnecki, Y Garini - PLoS One, 2015 - journals.plos.org
Single particle tracking is an essential tool in the study of complex systems and biophysics
and it is commonly analyzed by the time-averaged mean square displacement (MSD) of the …

[HTML][HTML] Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation

T Stylianopoulos, B Diop-Frimpong, LL Munn, RK Jain - Biophysical journal, 2010 - cell.com
The interstitial matrix is comprised of cross-linked collagen fibers, generally arranged in
nonisotropic orientations. Spatial alignment of matrix components within the tissue can affect …

[HTML][HTML] Hierarchical organization of the plasma membrane: investigations by single-molecule tracking vs. fluorescence correlation spectroscopy

A Kusumi, YM Shirai, I Koyama-Honda, KGN Suzuki… - FEBS letters, 2010 - Elsevier
Single-molecule tracking and fluorescence correlation spectroscopy (FCS) applied to the
plasma membrane in living cells have allowed a number of unprecedented observations …

Tracking single molecules in the live cell plasma membrane—Do's and Don't's

S Wieser, GJ Schütz - Methods, 2008 - Elsevier
In recent years, the development of fast and highly sensitive microscopy has changed the
way of thinking of cell biologists: it became more and more important to study the structural …

Membrane mechanisms for signal transduction: the coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein …

A Kusumi, TK Fujiwara, N Morone, KJ Yoshida… - Seminars in cell & …, 2012 - Elsevier
Virtually all biological membranes on earth share the basic structure of a two-dimensional
liquid. Such universality and peculiarity are comparable to those of the double helical …