The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups.
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of …

Adult neurogenesis arises from neural stem cells within specialized niches,,. Neuronal
activity and experience, presumably acting on this local niche, regulate multiple stages of …

From early embryonic development to adulthood, GABA release participates in the
construction of the mammalian cerebral cortex. The maturation of GABAergic …

GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

Recent years have witnessed a steep increase in studies on the diverse roles of neuronal
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …

In the last decade, many papers highlighted that the histone variant H2AX and its
phosphorylation on Ser 139 (γH2AX) cannot be simply considered a specific DNA double …

Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals
on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in …

It was long thought that no new neurons are added to the adult brain. Similarly,
neurotransmitter signaling was primarily associated with communication between …