Highlights•The Reactive Oxygen Species have an utmost importance in progression of
Depression.•Depression is associated with lowered concentration of anti-oxidants in …

Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

With the acceleration of population aging, nervous system diseases including Alzheimer's
disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression …

The longest-lived rodent, the naked mole-rat (Heterocephalus glaber), has a reported
maximum lifespan of> 30 years and exhibits delayed and/or attenuated age-associated …

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified
cellular housekeeping are the hallmarks of improved healthspan and extended lifespan …

Despite recent advances in molecular biology and genetics, the mysteries that control
human lifespan are yet to be unraveled. Many theories, which fall into two main categories …

Calorie restriction (CR), the reduction of dietary intake below energy requirements while
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …

Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

The concept of trade‐offs is central to our understanding of life‐history evolution. The
underlying mechanisms, however, have been little studied. Oxidative stress results from a …