High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

The extracellular signal-related kinases (ERKs) act as pleiotropic molecules in tumors,
where they activate pro-survival pathways leading to cell proliferation and migration, as well …

Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in
an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of …

Human cerebral cancers are known to contain cell types resembling the varying stages of
neural development. However, the basis of this association remains unclear. Here, we map …

Pyroptosis has been implicated in the pathophysiology of myocardial infarction (MI) in
rodents, but its contribution to reperfusion injury in MI patients is unclear. Here, we evaluated …

Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

AP-1 is a dimeric complex that is composed of JUN, FOS, ATF and MAF protein families.
FOS-related antigen 1 (FRA1) which encoded by FOSL1 gene, belongs to the FOS protein …

FRA1 (FOSL1) is a transcription factor and a member of the activator protein-1 superfamily.
FRA1 is expressed in most tissues at low levels, and its expression is robustly induced in …

Among the FOS-related members of the AP-1 dimeric complex, the transcription factor Fra-1,
encoded by FOSL1, is crucially involved in human tumor progression and metastasis, thus …

Reperfusion therapy is the most effective treatment for acute myocardial infarction. However,
reperfusion itself can also cause cardiomyocytes damage. Pyroptosis has been shown to be …