Oxygen-derived free radicals and related oxidants are ubiquitous and short-lived
intermediates formed in aerobic organisms throughout life. These reactive species …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Aggregated α-synuclein proteins form brain lesions that are hallmarks of neurodegenerative
synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of …

Protein oxidation is defined here as the covalent modification of a protein induced either
directly by reactive oxygen species or indirectly by reaction with secondary by-products of …

Peroxynitrite promotes oxidative damage and is implicated in the pathophysiology of various
diseases that involve accelerated rates of nitric oxide and superoxide formation. The …

The free radical-mediated damage to proteins results in the modification of amino acid
residues, cross-linking of side chains and fragmentation. l-Tyrosine and protein bound …

The free radical nitric oxide (NO•) exerts biological effects through the direct and reversible
interaction with specific targets (eg soluble guanylate cyclase) or through the generation of …

Abstract I. Introduction 00 II. Reactive Oxygen and Nitrogen Species 00 III. Biological
Markers of Oxidative/Nitrosative Stress 00 IV. Oxidative/Nitrosative Stress and Protein …

Protein 3-nitrotyrosine is a posttranslational modification found in many pathological
conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the …