Dendritic cell regulation of T helper cells
X Yin, S Chen, SC Eisenbarth - Annual review of immunology, 2021 - annualreviews.org
As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses
KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
[HTML][HTML] The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new
platform used by two leading vaccines against COVID-19. Clinical trials and ongoing …
platform used by two leading vaccines against COVID-19. Clinical trials and ongoing …
Trial watch: dendritic cell vaccination for cancer immunotherapy
J Sprooten, J Ceusters, A Coosemans… - …, 2019 - Taylor & Francis
Dendritic-cells (DCs) have received considerable attention as potential targets for the
development of anticancer vaccines. DC-based anticancer vaccination relies on patient …
development of anticancer vaccines. DC-based anticancer vaccination relies on patient …
Future considerations for the mRNA-lipid nanoparticle vaccine platform
BZ Igyártó, S Jacobsen, S Ndeupen - Current opinion in virology, 2021 - Elsevier
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) pioneered by Katalin
Karikó and Drew Weissman at the University of Pennsylvania are a promising new vaccine …
Karikó and Drew Weissman at the University of Pennsylvania are a promising new vaccine …
[HTML][HTML] MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity
Protective immune responses against respiratory pathogens, such as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …
[HTML][HTML] Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion
Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been
administered to humans. However, we lack a comprehensive understanding of the immune …
administered to humans. However, we lack a comprehensive understanding of the immune …
B cell response to vaccination
As one of the most important weapons against infectious diseases, vaccines have saved
countless lives since their first use in the late eighteenth century. Antibodies produced by …
countless lives since their first use in the late eighteenth century. Antibodies produced by …
Opportunities and challenges for mRNA delivery nanoplatforms
Y Zhang, Y Hu, H Tian, X Chen - The Journal of Physical …, 2022 - ACS Publications
With the global outbreak of SARS-CoV-2, mRNA vaccines became the first type of COVID-19
vaccines to enter clinical trials because of their facile production, low cost, and relative …
vaccines to enter clinical trials because of their facile production, low cost, and relative …
[HTML][HTML] Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques
R Marlin, V Godot, S Cardinaud, M Galhaut… - Nature …, 2021 - nature.com
Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require
additional approaches to currently approved viral vector and mRNA vaccines. Subunit …
additional approaches to currently approved viral vector and mRNA vaccines. Subunit …