Genome-edited powdery mildew resistance in wheat without growth penalties
Disruption of susceptibility (S) genes in crops is an attractive breeding strategy for conferring
disease resistance,. However, S genes are implicated in many essential biological functions …
disease resistance,. However, S genes are implicated in many essential biological functions …
[HTML][HTML] LncRNAs as chromatin regulators in cancer: from molecular function to clinical potential
R Begolli, N Sideris, A Giakountis - Cancers, 2019 - mdpi.com
During the last decade, high-throughput sequencing efforts in the fields of transcriptomics
and epigenomics have shed light on the noncoding part of the transcriptome and its …
and epigenomics have shed light on the noncoding part of the transcriptome and its …
DeepLoop robustly maps chromatin interactions from sparse allele-resolved or single-cell Hi-C data at kilobase resolution
Mapping chromatin loops from noisy Hi-C heatmaps remains a major challenge. Here we
present DeepLoop, which performs rigorous bias correction followed by deep-learning …
present DeepLoop, which performs rigorous bias correction followed by deep-learning …
Enhancer release and retargeting activates disease-susceptibility genes
The functional engagement between an enhancer and its target promoter ensures precise
gene transcription. Understanding the basis of promoter choice by enhancers has important …
gene transcription. Understanding the basis of promoter choice by enhancers has important …
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes
NJ Rinzema, K Sofiadis, SJD Tjalsma… - Nature Structural & …, 2022 - nature.com
Developmental gene expression is often controlled by distal regulatory DNA elements called
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …
PRC2. 1-and PRC2. 2-specific accessory proteins drive recruitment of different forms of canonical PRC1
Summary Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization
B Pelham-Webb, A Polyzos, L Wojenski, A Kloetgen… - Molecular cell, 2021 - cell.com
During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …
Guilt by association: EcDNA as a mobile transactivator in cancer
Extrachromosomal DNA (ecDNA), first described in the 1960s, is emerging as a prevalent
but poorly characterized oncogenic alteration in cancer. ecDNA is a reservoir for oncogene …
but poorly characterized oncogenic alteration in cancer. ecDNA is a reservoir for oncogene …
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
D Murphy, E Salataj, DC Di Giammartino… - Nature Structural & …, 2024 - nature.com
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …
Replication dynamics identifies the folding principles of the inactive X chromosome
R Poonperm, S Ichihara, H Miura, A Tanigawa… - Nature Structural & …, 2023 - nature.com
Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome
(Xi). How it is established and what it represents remains obscure. By single-cell DNA …
(Xi). How it is established and what it represents remains obscure. By single-cell DNA …