Phenotype-based screening has emerged as an alternative route for discovering new
chemical entities toward first-in-class therapeutics. However, clarifying their mode of action …

Drug target deconvolution can accelerate the drug discovery process by identifying a drug's
targets (facilitating medicinal chemistry efforts) and off-targets (anticipating toxicity effects or …

Various agents, including drugs as well as nonmolecular stimuli, induce alterations in the
physicochemical properties of proteins in cell lysates, living cells, and organisms. These …

Detecting the targets of drugs and other molecules in intact cellular contexts is a major
objective in drug discovery and in biology more broadly. Thermal proteome profiling (TPP) …

Thermal proteome profiling (TPP) provides a powerful approach to studying proteome-wide
interactions of small therapeutic molecules and their target and off-target proteins …

The cellular thermal shift assay (CETSA) is a biophysical technique allowing direct studies of
ligand binding to proteins in cells and tissues. The proteome-wide implementation of CETSA …

The purpose of this project report is to introduce the European “GOLIATH” project, a new
research project which addresses one of the most urgent regulatory needs in the testing of …

Natural products (NPs) have been an important source of therapeutic drugs in clinic use and
contributed many chemical probes for research. The usefulness of NPs is however often …

In past times, the analysis of endocrine disrupting properties of chemicals has mainly been
focused on (anti-) estrogenic or (anti-) androgenic properties, as well as on aspects of …

Glyphosate is the world's most widely used herbicide, and its potential side effects on the
intestinal microbiota of various animals, from honeybees to livestock and humans, are …