We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Widespread appreciation that neuroplasticity is an essential feature of the neural system
controlling breathing has emerged only in recent years. In this chapter, we focus on …

Inflammation undermines neuroplasticity, including serotonin-dependent phrenic long-term
facilitation (pLTF) following moderate acute intermittent hypoxia (mAIH: 3, 5-min episodes …

Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in
humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined …

After spinal cord injury (SCI) respiratory complications are a leading cause of morbidity and
mortality. Acute intermittent hypoxia (AIH) triggers spinal respiratory motor plasticity in rodent …

Background Inflammation undermines multiple forms of neuroplasticity. Although
inflammation and its influence on plasticity in multiple neural systems has been extensively …

Acute intermittent hypoxia (AIH) elicits long‐term facilitation (LTF) of respiration. Although
LTF is observed when CO2 is elevated during AIH in awake humans, the influence of CO2 …

Plasticity is a fundamental property of neural systems, defined as a persistent change in
neural system morphology and function based on prior experience. Experiences initiating …

Plasticity is a fundamental property of the neural system controlling breathing. One key
example of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a persistent …

An important model of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a
persistent increase in phrenic burst amplitude following acute intermittent hypoxia (AIH) …