RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …

Low back pain stands as a pervasive global health concern, afflicting almost 80% of adults
at some point in their lives with nearly 40% attributable to intervertebral disc degeneration …

The use of lipid nanoparticles (LNPs) for therapeutic RNA delivery has gained significant
interest, particularly highlighted by recent milestones such as the approval of Onpattro and …

Abstract Design of inhalable mRNA therapeutics is promising because local administration
in the respiratory tract is minimally invasive and induces a local response. However, several …

Lipid nanoparticles (LNPs) produced by antisolvent precipitation (ASP) are used in
formulations for mRNA drug delivery. The mesoscopic structure of such complex …

Microfluidic technology has emerged as a prevalent tool to produce lipid nanoparticles
(LNPs) for nucleic acid delivery. However, its wide-ranging application is hindered by …

When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are
encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear …

Macrophages are unique immune cells attracting growing attention as a potential candidate
for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme …

Introduction The mRNA vaccine technologies have progressed rapidly in recent years. The
COVID-19 pandemic has accelerated the application of mRNA vaccines, with research and …

Introduction mRNA therapeutics were a niche area in drug development before
COVIDvaccines. Now they are used in vaccine development, for non-viral …