Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Abstract γ-aminobutyric acid type B (GABA B) receptors are broadly expressed in the
nervous system and play an important role in neuronal excitability. GABA B receptors are G …

Ethanol is a chemically simple compound that produces many well-known effects in
humans. The prevailing idea for many years was that ethanol and other alcohols exerted …

The cholinergic and glutamatergic neurotransmission systems are known to be severely
disrupted in Alzheimer's disease (AD). GABAergic neurotransmission, in contrast, is …

The hypothalamic-pituitary-adrenal (HPA) axis, which mediates the body's response to
stress, is largely under GABAergic control. Here we demonstrate that corticotropin-releasing …

The master clock in the suprachiasmatic nuclei (SCN) is composed of multiple, single-cell
circadian clocks. We test the postulate that these individual" clock cells" can be …

A major challenge in understanding complex idiopathic generalized epilepsies has been the
characterization of their underlying molecular genetic basis. Here, we report that genetic …

Following cloning of the vanilloid receptor 1 (VR1) at least four other related proteins have
been identified. Together, these form a distinct subgroup of the transient receptor potential …

Recent FDA approval of an allopregnanolone-based treatment specifically for postpartum
depression, brexanolone, now commercially called Zulresso®, is an exciting development …