Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Cytotoxic lymphocyte-derived granzyme A (GZMA) cleaves GSDMB, a gasdermin-family
pore-forming protein,, to trigger target cell pyroptosis. GSDMB and the charter gasdermin …

Abstract The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11;
hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce …

The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions
by secreting multiple effectors with diverse biochemical activities. In particular, effectors of …

Host organisms utilise a range of genetically encoded cell death programmes in response to
pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their …

Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an
attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other …

The blood–brain barrier (BBB) protects the central nervous system from infections or harmful
substances; its impairment can lead to or exacerbate various diseases of the central nervous …

Objective The protein post-translational modification (PTM) in host cells can be rewritten by
bacterial enzymes and represents an unprecedented mechanism in the communication …

Two decades of inflammasome research has led to a vast body of knowledge on the
complex regulatory mechanisms and pathological roles of canonical and non-canonical …