Abstract Hydrogen peroxide (H 2 O 2) detection is paramount in biological and clinical
domains due to its pivotal role in various physiological and pathological processes. This …

Designing and discovering compounds for dual-target inhibitors is challenging to synthesize
new, safer, and more efficient drugs than single-target drugs, especially to treat multifactorial …

For decades now, computational chemistry has allowed us to shorten experimental times to
meet the needs of humanity in finding solutions. In this regard, we tried to exploit tools such …

Ordinary small molecule de novo drug design is time-consuming and expensive. Recently,
computational tools were employed and proved their efficacy in accelerating the overall drug …

The ubiquitin‐proteasome pathway (UPP) represents the principal proteolytic apparatus in
the cytosol and nucleus of all eukaryotic cells. Nowadays, proteasome inhibitors (PIs) are …

Benzomorphans have been investigated in medicinal chemistry for developing new drugs.
This nucleus could be considered a versatile scaffold. The physicochemical properties of …

In recent decades, many efforts have been devoted to studying reactions catalyzed in
nanoconfined spaces. The most impressive aspect of catalysis in nanoconfined spaces is …

As the world transitions from the acute phase of the COVID‐19 pandemic caused by SARS‐
CoV‐2, the scientific community continues to explore various therapeutic avenues to control …

Staphylococcus aureus, a notorious member of the ESKAPE pathogens, poses significant
public health challenges due to its virulence and multidrug-resistant nature, particularly in …

Suitable structural modifications of the functional groups at N‐substituent of (−)‐cis‐N‐
normetazocine nucleus modulate the affinity and activity profile of related ligands toward …