Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric
states such as intermittent fasting have beneficial effects on organismal health and age …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

The epithelial tissues that line our body, such as the skin and gut, have remarkable
regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier …

Satellite cells are required for the growth, maintenance, and regeneration of skeletal muscle.
Quiescent satellite cells possess a primary cilium, a structure that regulates the processing …

Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption
and associated illnesses, yet its aging mechanisms remain unclear. Here, we show that …

Regenerative processes that maintain the function of the gastrointestinal (GI) epithelium are
critical for health and survival of multicellular organisms. In insects and vertebrates, intestinal …