Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

Highlights•SAXS captures architecture and dynamics to elucidate molecular
ensembles.•SAXS advances now probe key thermodynamic and kinetic properties of …

While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now
recognized, deciphering their molecular mode of action at the structural level still remains …

The recent innovation of collecting X-ray scattering from solutions containing purified
macromolecules in high-throughput has yet to be truly exploited by the biological …

Small-angle X-ray scattering (SAXS) is a robust technique for the comprehensive structural
characterizations of biological macromolecular complexes in solution. Here, we present a …

O6-Alkylguanine-DNA alkyltransferase (AGT) is a crucial target both for the prevention of
cancer and for chemotherapy, since it repairs mutagenic lesions in DNA, and it limits the …

Multidomain proteins in which consecutive globular regions are connected by linkers are
prevalent in nature (Levitt in Proc Natl Acad Sci USA 106: 11079–11084, 2009). Some …

The first implementation and use of an in situ size exclusion chromatography (SEC) system
on a small-angle neutron scattering instrument (SANS) is described. The possibility of …

Adaptive immune systems have recently been recognized in prokaryotic organisms where,
in response to viral infection, they incorporate short fragments of invader-derived DNA into …