Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
Aristolochic acid-associated cancers: a public health risk in need of global action
S Das, S Thakur, M Korenjak, VS Sidorenko… - Nature Reviews …, 2022 - nature.com
Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme
A Sosinsky, J Ambrose, W Cross, C Turnbull… - Nature Medicine, 2024 - nature.com
Abstract The Cancer Programme of the 100,000 Genomes Project was an initiative to
provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities …
provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities …
The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells
GCC Koh, S Boushaki, SJ Zhao, AM Pregnall… - Nature Genetics, 2024 - nature.com
The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …
[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers
Abstract Analysis of mutational signatures can reveal underlying molecular mechanisms of
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
[HTML][HTML] Homologous recombination repair deficiency: an overview for pathologists
The repair of DNA double-stranded breaks relies on the homologous recombination repair
pathway and is critical to cell function. However, this pathway can be lost in some cancers …
pathway and is critical to cell function. However, this pathway can be lost in some cancers …
Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment
Motivation Analysis of mutational signatures is a powerful approach for understanding the
mutagenic processes that have shaped the evolution of a cancer genome. To evaluate the …
mutagenic processes that have shaped the evolution of a cancer genome. To evaluate the …
Implementation of whole-genome and transcriptome sequencing into clinical cancer care
E Cuppen, O Elemento, R Rosenquist, S Nikic… - JCO Precision …, 2022 - ascopubs.org
PURPOSE The combination of whole-genome and transcriptome sequencing (WGTS) is
expected to transform diagnosis and treatment for patients with cancer. WGTS is a …
expected to transform diagnosis and treatment for patients with cancer. WGTS is a …