The fusion of pyrazole scaffold with other skeletons creates a class of attractive molecules,
demonstrating significant biological and chemical potentiality in the development of …

The treatment of central nervous system (CNS) malignancies, including brain cancers, is
limited by a number of obstructions, including the blood-brain barrier (BBB), the …

Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …

Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …

Pyrazole-containing compounds represent one of the most influential families of N-
heterocycles due to their proven applicability and versatility as synthetic intermediates in …

Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This
scaffold produced numerous biological activities in which anticancer is important one …

An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives has been developed.
It involves a [3+ 2+ 1] three-component annulation of amidines, ketones, and one carbon …

Pyrazolopyrimidine with all its isoforms occupy a noteworthy position in medicinal chemistry
owing to their proven dominance in the modulation of a vast array of biological receptors …

The cyclin-dependent kinases (CDKs) play a crucial role in cell cycle progression and are
validated targets of cancer therapy. Pyrazolopyrimidines are versatile scaffolds, which have …

A new method has been developed for the C–H selenylation of pyrazolo [1, 5-a] pyrimidine
derivatives under the irradiation of visible light. This photocatalyst-free strategy is applicable …