Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …

The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …

Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic aneurysm
and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass …

Aortic dissection progresses mainly via delamination of the medial layer of the wall.
Notwithstanding the complexity of this process, insight has been gleaned by studying in vitro …

This review discusses sexual dimorphism in arterial stiffening, disease pathology
interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness …

Elastic and collagen fibers are well known to be the major load-bearing extracellular matrix
(ECM) components of the arterial wall. Studies of the structural components and mechanics …

Elastic and muscular arteries differ in structure, function, and mechanical properties, and
may adapt differently to aging. We compared the descending thoracic aortas (TA) and the …

Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition associated
with Marfan syndrome (MFS), a disease caused by fibrillin-1 gene mutations. While various …

Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …

Aging leads to central artery stiffening and associated hemodynamic sequelae. Because
healthy arteries exhibit differential geometry, composition, and mechanical behaviors along …