Lipolysis: cellular mechanisms for lipid mobilization from fat stores

GF Grabner, H Xie, M Schweiger, R Zechner - Nature metabolism, 2021 - nature.com
The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Lipid droplets and cellular lipid metabolism

TC Walther, RV Farese Jr - Annual review of biochemistry, 2012 - annualreviews.org
Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …

FAT SIGNALS-lipases and lipolysis in lipid metabolism and signaling

R Zechner, R Zimmermann, TO Eichmann… - Cell metabolism, 2012 - cell.com
Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets.
Recent discoveries of essential lipolytic enzymes and characterization of numerous …

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

TS Nielsen, N Jessen, JOL Jørgensen… - Journal of …, 2014 - jme.bioscientifica.com
Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …

Regulation of adipocyte lipolysis

G Frühbeck, L Méndez-Giménez… - Nutrition research …, 2014 - cambridge.org
In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

[HTML][HTML] Lipolysis–a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

A Lass, R Zimmermann, M Oberer, R Zechner - Progress in lipid research, 2011 - Elsevier
Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …

Lipolysis and lipid mobilization in human adipose tissue

M Lafontan, D Langin - Progress in lipid research, 2009 - Elsevier
Triacylglycerol (TAG) stored in adipose tissue (AT) can be rapidly mobilized by the hydrolytic
action of the three main lipases of the adipocyte. The non-esterified fatty acids (NEFA) …

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

PE Bickel, JT Tansey, MA Welte - … et Biophysica Acta (BBA)-Molecular and …, 2009 - Elsevier
The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose
differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3–12, and …

Recent progress in phospholipase A2 research: from cells to animals to humans

M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

F Wilfling, AR Thiam, MJ Olarte, J Wang, R Beck… - elife, 2014 - elifesciences.org
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids, such as
triacylglycerol (TG), as reservoirs of metabolic energy and membrane precursors. The …