Clinical aspects of snakebite envenoming and its treatment in low-resource settings

DA Warrell, DJ Williams - The Lancet, 2023 - thelancet.com
There is increasing recognition of the public health importance of snakebite envenoming.
Worldwide annual incidence is likely to be 5 million bites, with mortality exceeding 150 000 …

A current perspective on snake venom composition and constituent protein families

T Tasoulis, GK Isbister - Archives of Toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …

Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity

X Ye, C He, Y Yang, YH Sun, S Xiong… - Genome …, 2023 - genome.cshlp.org
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …

The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom

MP Hogan, ML Holding, GS Nystrom… - Proceedings of the …, 2024 - National Acad Sciences
Developmental phenotypic changes can evolve under selection imposed by age-and size-
related ecological differences. Many of these changes occur through programmed …

[HTML][HTML] Genome evolution and the future of phylogenomics of non-avian reptiles

DC Card, WB Jennings, SV Edwards - Animals, 2023 - mdpi.com
Simple Summary As a group of organisms, non-avian reptiles, most of which are the~
11,000 species of lizards and snakes, are an extraordinarily diverse group, displaying a …

Origins, genomic structure and copy number variation of snake venom myotoxins

SS Gopalan, BW Perry, DR Schield, CF Smith… - Toxicon, 2022 - Elsevier
Crotamine, myotoxin a and homologs are short peptides that often comprise major fractions
of rattlesnake venoms and have been extensively studied for their bioactive properties …

[HTML][HTML] Gene communities in co-expression networks across different tissues

M Russell, A Aqil, M Saitou, O Gokcumen… - PLOS Computational …, 2023 - journals.plos.org
With the recent availability of tissue-specific gene expression data, eg, provided by the GTEx
Consortium, there is interest in comparing gene co-expression patterns across tissues. One …

ToxCodAn-Genome: an automated pipeline for toxin-gene annotation in genome assembly of venomous lineages

PG Nachtigall, AM Durham, DR Rokyta… - …, 2024 - academic.oup.com
Background The rapid development of sequencing technologies resulted in a wide
expansion of genomics studies using venomous lineages. This facilitated research focusing …

Single-cell heterogeneity in snake venom expression is hardwired by co-option of regulators from progressively activated pathways

AK Westfall, SS Gopalan, BW Perry… - Genome Biology and …, 2023 - academic.oup.com
The ubiquitous cellular heterogeneity underlying many organism-level phenotypes raises
questions about what factors drive this heterogeneity and how these complex …

Morphological, functional, compositional and transcriptional constraints shape the distinct venom profiles of the assassin bug Sycanus croceovittatus

C Wu, L Li, Y Wang, S Wei, J Zhu - International Journal of Biological …, 2023 - Elsevier
Predatory bugs employ a salivary venom apparatus to generate complex venoms for
capturing and digesting prey. The venom apparatus consists of different glands for the …