Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue,
obesity-mediated insulin resistance correlates with the accumulation of proinflammatory …

A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and
adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) …

Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

Abstract mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of
insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid metabolism …

Adipose tissue de novo lipogenesis (DNL) positively influences insulin sensitivity, is reduced
in obesity, and predicts insulin resistance. Therefore, elucidating mechanisms controlling …

Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …