[HTML][HTML] Forces in tissue morphogenesis and patterning

CP Heisenberg, Y Bellaïche - Cell, 2013 - cell.com
During development, mechanical forces cause changes in size, shape, number, position,
and gene expression of cells. They are therefore integral to any morphogenetic processes …

Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System

DP Kiehart, JM Crawford, A Aristotelous… - Annual review of cell …, 2017 - annualreviews.org
Dorsal closure is a key process during Drosophila morphogenesis that models cell sheet
movements in chordates, including neural tube closure, palate formation, and wound …

Rapid disorganization of mechanically interacting systems of mammary acini

Q Shi, RP Ghosh, H Engelke… - Proceedings of the …, 2014 - National Acad Sciences
Cells and multicellular structures can mechanically align and concentrate fibers in their ECM
environment and can sense and respond to mechanical cues by differentiating, branching …

Probing embryonic tissue mechanics with laser hole drilling

X Ma, HE Lynch, PC Scully, MS Hutson - Physical biology, 2009 - iopscience.iop.org
We use laser hole drilling to assess the mechanics of an embryonic epithelium during
development—in vivo and with subcellular resolution. We ablate a subcellular cylindrical …

Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis

WY Ding, HT Ong, Y Hara, J Wongsantichon… - Journal of Cell …, 2017 - rupress.org
The cell cortex is essential to maintain animal cell shape, and contractile forces generated
within it by nonmuscle myosin II (NMY-2) drive cellular morphogenetic processes such as …

Cell boundary elongation by non-autonomous contractility in cell oscillation

Y Hara, M Shagirov, Y Toyama - Current Biology, 2016 - cell.com
Throughout development, tissues exhibit dynamic cell deformation, which is characterized
by the integration of cell boundary contraction and/or elongation. Such changes ultimately …

A minimal vertex model explains how the amnioserosa avoids fluidization during Drosophila dorsal closure

I Tah, D Haertter, JM Crawford, DP Kiehart… - Proceedings of the …, 2025 - pnas.org
Dorsal closure is a process that occurs during embryogenesis of Drosophila melanogaster.
During dorsal closure, the amnioserosa (AS), a one-cell thick epithelial tissue that fills the …

Cell ingression and apical shape oscillations during dorsal closure in Drosophila

A Sokolow, Y Toyama, DP Kiehart, GS Edwards - Biophysical journal, 2012 - cell.com
Programmed patterns of gene expression, cell-cell signaling, and cellular forces cause
morphogenic movements during dorsal closure. We investigated the apical cell-shape …

Wound repair in sea urchin larvae involves pigment cells and blastocoelar cells

RL Allen, AN George, E Miranda, TM Phillips… - Developmental …, 2022 - Elsevier
Sea urchin larvae spend weeks to months feeding on plankton prior to metamorphosis.
When handled in the laboratory they are easily injured, suggesting that in the plankton they …

Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila development

XG Peralta, Y Toyama, MS Hutson, R Montague… - Biophysical journal, 2007 - cell.com
Tissue dynamics during dorsal closure, a stage of Drosophila development, provide a model
system for cell sheet morphogenesis and wound healing. Dorsal closure is characterized by …