Candidiasis is the most common opportunistic yeast infection. Candida species and other
microorganisms are involved in this complicated fungal infection, but Candida albicans …

Fungal vacuoles are acidic organelles with degradative and storage capabilities that have
many similarities to mammalian lysosomes and plant vacuoles. In the past several years …

Candida albicans is a normal resident of the gastrointestinal tract and also the most
prevalent fungal pathogen of humans. It last shared a common ancestor with the model …

Maintaining the appropriate balance of iron between deficiency and toxicity requires fine-
tuned control of systems for iron uptake and storage. Both among fungal species and within …

Plants remodel their cells through the dynamic endomembrane system. Intracellular pH is
important for membrane trafficking, but the determinants of pH homeostasis are poorly …

All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in
organelle acidification. Not only is the structure of V-ATPases highly conserved among …

Many fungi grow over a wide pH range and their gene expression is tailored to the
environmental pH. In Aspergillus nidulans, the transcription factor PacC, an activator of …

Vacuolar proton-translocating ATPases (V-ATPases) play a central role in organelle
acidification in all eukaryotic cells. To address the role of the yeast V-ATPase in vacuolar …

Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol
biosynthesis, although the cellular basis for their antifungal activity is not understood. We …

Using two types of genome-wide analysis to investigate yeast genes involved in response to
lactic acid and acetic acid, we found that the acidic condition affects metal metabolism. The …