Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant
roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its …

Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

Tumor necrosis factor (TNF) is a pleiotropic cytokine powerfully influencing diverse
processes of the central nervous system (CNS) under both physiological and pathological …

Multiple sclerosis (MS) is a common neurological disorder of putative autoimmune origin.
Clinical and experimental studies delineate abnormal expression of specific cytokines over …

Abstract Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder
characterized by senile plaques and neurofibrillary tangles, is the most common form of …

The pathology in neurodegenerative diseases is often accompanied by inflammation. It is
well-known that many cells within the central nervous system (CNS) also contribute to …

TNF is a key proinflammatory and immunoregulatory cytokine whose deregulation is
associated with the development of autoimmune diseases and other pathologies. Recent …

Neurodegenerative diseases currently affect millions of people worldwide and continues to
increase in the expanding elderly population. Neurodegenerative diseases usually involve …

A leading cause of preterm birth is the exposure to systemic inflammation (maternal/fetal
infection), which leads to neuroinflammation and white matter injury (WMI). A wide range of …