Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological
mechanisms of which remain poorly understood. Despite decades of speculation regarding …

Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies
have highlighted the public health relevance of this association, insofar as both conditions …

Multiple sources of evidence support a role for diminished dopaminergic neurotrans-mission
in major depression. The physiological alterations underlying reduced dopa-mine (DA) …

OBJECTIVE: Anhedonia, the lack of reactivity to pleasurable stimuli, is a cardinal feature of
depression that has received renewed interest as a potential endophenotype of this …

Depression is characterised partly by blunted reactions to reward. However, tasks probing
this deficiency have not distinguished insensitivity to reward from insensitivity to the …

Background Previous work has shown that chronic social defeat stress (CSDS) induces
increased phasic firing of ventral tegmental area (VTA) dopamine (DA) neurons that project …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The genetic basis of major depressive disorder (MDD) has been investigated extensively,
but the identification of MDD genes has been hampered by conflicting results from …

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Objective: Rational therapeutic development in bipolar is hampered by a lack of
pathophysiological model. However, there is a wealth of converging data on the role of …