Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …
considered two of the most important causes of death. Experimental and clinical evidence …
Metformin as an anti-inflammatory agent: a short review
R Kristófi, JW Eriksson - Journal of Endocrinology, 2021 - joe.bioscientifica.com
Metformin is a biguanide drug widely used as the initial treatment of type 2 diabetes. Despite
its widespread use, its precise mechanisms of action remain incompletely characterised. Its …
its widespread use, its precise mechanisms of action remain incompletely characterised. Its …
[HTML][HTML] Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis
Z Wang, M Yao, L Jiang, L Wang, Y Yang… - Biomedicine & …, 2022 - Elsevier
The present study aimed to investigate whether dexmedetomidine (Dex) exerts
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …
Salidroside ameliorates Alzheimer's disease by targeting NLRP3 inflammasome-mediated pyroptosis
Y Cai, Y Chai, Y Fu, Y Wang, Y Zhang… - Frontiers in aging …, 2022 - frontiersin.org
Amyloid β-protein (Aβ) is reported to activate NLRP3 inflammasomes and drive pyroptosis,
which is subsequently involved in the pathogenesis of neurodegenerative diseases, such as …
which is subsequently involved in the pathogenesis of neurodegenerative diseases, such as …
AMPK: The key to ischemia‐reperfusion injury
J Cai, X Chen, X Liu, Z Li, A Shi, X Tang… - Journal of cellular …, 2022 - Wiley Online Library
Ischemia‐reperfusion injury (IRI) refers to a syndrome in which tissue damage is further
aggravated and organ function further deteriorates when blood flow is restored after a period …
aggravated and organ function further deteriorates when blood flow is restored after a period …
Spatiotemporal On–Off Immunomodulatory Hydrogel Targeting NLRP3 Inflammasome for the Treatment of Biofilm‐Infected Diabetic Wounds
J Zhou, J Mei, Q Liu, D Xu, X Wang… - Advanced Functional …, 2023 - Wiley Online Library
Biofilm‐infected diabetic wounds (BIDWs) with hyperglycemia and bacterial colonization are
characterized by disordered inflammation and abnormal activation of NLRP3 …
characterized by disordered inflammation and abnormal activation of NLRP3 …
NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injury
R Prakash, A Vyawahare, R Sakla, N Kumari… - ACS …, 2023 - ACS Publications
Ischemia–reperfusion (I/R) injury is a disease process that affects several vital organs. There
is widespread agreement that the NLRP3 inflammasome pathway plays a crucial role in the …
is widespread agreement that the NLRP3 inflammasome pathway plays a crucial role in the …
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome‐Induced Pyroptosis via Inhibiting the TLR4/NF‐κB/PFKFB3 Signaling in …
Y Zhang, W Liu, Y Zhong, Q Li, M Wu… - Oxidative Medicine …, 2021 - Wiley Online Library
NOD‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome‐
mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with …
mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with …
Protective effects of metformin in various cardiovascular diseases: clinical evidence and AMPK‐dependent mechanisms
Y Bu, M Peng, X Tang, X Xu, Y Wu… - Journal of Cellular …, 2022 - Wiley Online Library
Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for
treating type 2 diabetes. There had been a significant concern regarding the use of …
treating type 2 diabetes. There had been a significant concern regarding the use of …
[HTML][HTML] Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion
K Zhang, T Wang, GF Sun, JX Xiao, LP Jiang… - Free Radical Biology …, 2023 - Elsevier
Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for
cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin …
cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin …