Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Abstract Background Cancer stem cells (CSCs) play crucial role in tumor progression, drug
resistance and relapse in various cancers. CSC niche is comprised of various stromal cell …

Glioblastoma is highly enriched with macrophages, and osteopontin (OPN) expression
levels correlate with glioma grade and the degree of macrophage infiltration; thus, we …

Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …

Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …

Osteopontin (OPN) is a multifunctional cytokine that impacts cell proliferation, survival, drug
resistance, invasion, and stem like behavior. Due to its critical involvement in regulating …

Osteopontin (OPN) is a multifunctional phosphorylated protein. It is widely involved in solid
tumor progression, such as intensification of macrophage recruitment, inhibition of T-cell …

Complex interactions between tumor and host cells regulate systemic tumor dissemination,
a process that begins early at the primary tumor site and goes on until tumor cells detach …

Abstract Osteopontin (OPN), a chemokine-like protein, plays a crucial role in the proliferation
and metastasis of various cancers. However, how tumor stroma modulates the expression of …