The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …

Smooth muscle cell migration has been implicated in the development of respiratory and
cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized …

Fibroblasts do not only serve as matrix-producing reparative cells, but exhibit a wide range
of functions in inflammatory and immune responses, angiogenesis and neoplasia. The adult …

In response to myocardial infarction (MI), the wound healing response of the left ventricle
(LV) comprises overlapping inflammatory, proliferative, and maturation phases, and the …

Heart failure is a leading cause of death worldwide. While there are multiple etiologies
contributing to the development of heart failure, all cause result in impairments in cardiac …

Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …

Myocardial infarction (MI) is defined as evidence of myocardial necrosis consistent with
prolonged ischemia. In response to MI, the myocardium undergoes a series of wound …

Diabetic cardiomyopathy (DCM) is a serious cardiovascular complication and the leading
cause of death in diabetic patients. Patients typically do not experience any symptoms and …

Diet High in salt content have been associated with cardiovascular disease and chronic
inflammation. We recently demonstrated that transient receptor potential canonical 3 …