Recently, a number of synthetic biologic gates including AND, OR, NOR, NOT, XOR and
NAND have been engineered and characterized in a wide range of hosts. The hope in the …

Synthetic biology may be viewed as an effort to establish, formalize, and develop an
engineering discipline in the context of biological systems. The ability to tune the properties …

Synthetic biology includes an effort to use design-based approaches to create novel
controllers, biological systems aimed at regulating the output of other biological processes …

Modularity in controlling gene expression artificially is becoming an essential aspect of
synthetic biology. Artificial transcriptional control of gene expression is one of the most well …

We have constructed and characterized two synthetic AND-gate promoters that require both
a quorum-sensing (QS) signal and an exogenously added inducer to turn on gene …

Advancement of in-cell molecular computation requires multi-input-multi-output genetic logic
devices. However, increased physical size, a higher number of molecular interactions, cross …

Background Frame-shifted genes results in non-functional peptides. Because of this
complete loss of function, frame-shifted genes have never been used in constructing …

Light-switchable proteins offer numerous opportunities as tools for manipulating biological
systems with exceptional degrees of spatiotemporal control. Most designed light-switchable …

The potential design space for biological systems is complex, vast and multidimensional.
Therefore, effective large-scale synthetic biology requires computational design and …

Light-switchable proteins are being used increasingly to understand and manipulate
complex molecular systems. The success of this approach has fueled the development of …