Host-directed immunotherapy of viral and bacterial infections: past, present and future
The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
Tuberculous meningitis: progress and remaining questions
J Huynh, J Donovan, NH Phu, HDT Nghia… - The Lancet …, 2022 - thelancet.com
Tuberculous meningitis is a devastating brain infection that is caused by Mycobacterium
tuberculosis and is notoriously difficult to diagnose and treat. New technologies …
tuberculosis and is notoriously difficult to diagnose and treat. New technologies …
[HTML][HTML] Therapeutic host-directed strategies to improve outcome in tuberculosis
Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …
has limited efficacy against pulmonary TB disease development and modest protection …
The pathogenesis of tuberculous meningitis
AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
[HTML][HTML] The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes
Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the
cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial …
cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial …
The neurocritical care of tuberculous meningitis
Tuberculous meningitis is the most severe form of tuberculosis and often causes critical
illness with high mortality. Two primary management objectives are reducing intracranial …
illness with high mortality. Two primary management objectives are reducing intracranial …
Resolution of neuroinflammation: mechanisms and potential therapeutic option
N Dokalis, M Prinz - Seminars in immunopathology, 2019 - Springer
The central nervous system (CNS) is comprised by an elaborate neural network that is under
constant surveillance by tissue-intrinsic factors for maintenance of its homeostasis. Invading …
constant surveillance by tissue-intrinsic factors for maintenance of its homeostasis. Invading …
The immune mechanisms of lung parenchymal damage in tuberculosis and the role of host-directed therapy
Impaired lung function is common in people with a history of tuberculosis. Host-directed
therapy added to tuberculosis treatment may reduce lung damage and result in improved …
therapy added to tuberculosis treatment may reduce lung damage and result in improved …
Tuberculous meningitis: where to from here?
J Donovan, GE Thwaites, J Huynh - Current opinion in infectious …, 2020 - journals.lww.com
Tuberculous meningitis still kills or disables around half of sufferers. Although some
progress has been made, there remains a need for more sensitive diagnostic tests, better …
progress has been made, there remains a need for more sensitive diagnostic tests, better …