Biomolecules are the prime information processing elements of living matter. Most of these
inanimate systems are polymers that compute their own structures and dynamics using as …

Recognition and binding of specific sites on DNA by proteins is central for many cellular
functions such as transcription, replication, and recombination. In the search for its target …

Rapid recognition of DNA target sites involves facilitated diffusion through which alternative
sites are searched on genomic DNA. A key mechanism facilitating the localization of the …

Intrinsically disordered proteins (IDP) are a broad class of proteins with relatively flat energy
landscapes showing a high level of functional promiscuity, which are frequently regulated …

DNA binding by the ETS transcriptional repressor ETV6 (or TEL) is auto-inhibited~ 50-fold
due to an α-helix that sterically blocks its ETS domain binding interface. Using NMR …

Intrinsically disordered proteins are highly abundant in nature and play a number of crucial
roles in the living cells. They are commonly involved in a wide range of intermolecular …

Aptamers are short single-stranded DNA or RNA oligonucleotides that can bind to their
targets with high affinity and specificity. Usually, they are experimentally selected using the …

A fundamental step in gene-regulatory activities, such as repression, transcription, and
recombination, is the binding of regulatory DNA-binding proteins (DBPs) to specific targets …

Formation of protein–DNA complex is an important step in regulation of genes in living
organisms. One important issue in this problem is the role played by water in mediating the …

The notion of energy landscapes provides conceptual tools for understanding the
complexities of protein folding and function. Energy landscape theory indicates that it is …