The road to restoring neural circuits for the treatment of Alzheimer's disease

RG Canter, J Penney, LH Tsai - Nature, 2016 - nature.com
Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …

Emerging technologies for improved deep brain stimulation

H Cagnan, T Denison, C McIntyre, P Brown - Nature biotechnology, 2019 - nature.com
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …

Neuroprosthetics: from sensorimotor to cognitive disorders

A Gupta, N Vardalakis, FB Wagner - Communications biology, 2023 - nature.com
Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

M Jakobs, A Fomenko, AM Lozano… - EMBO molecular …, 2019 - embopress.org
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

Neural oscillations and brain stimulation in Alzheimer's disease

Z Jafari, BE Kolb, MH Mohajerani - Progress in neurobiology, 2020 - Elsevier
Aging is associated with alterations in cognitive processing and brain neurophysiology.
Whereas the primary symptom of amnestic mild cognitive impairment (aMCI) is memory …

Brain stimulation in Alzheimer's disease

CH Chang, HY Lane, CH Lin - Frontiers in psychiatry, 2018 - frontiersin.org
Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric
diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's …

Modulation of human memory by deep brain stimulation of the entorhinal-hippocampal circuitry

EA Mankin, I Fried - Neuron, 2020 - cell.com
Neurological disorders affecting human memory present a major scientific, medical, and
societal challenge. Direct or indirect deep brain stimulation (DBS) of the entorhinal …

Revolution of Alzheimer precision neurology. Passageway of systems biology and neurophysiology

H Hampel, N Toschi, C Babiloni… - Journal of …, 2018 - content.iospress.com
The Precision Neurology development process implements systems theory with system
biology and neurophysiology in a parallel, bidirectional research path: a combined …

Deep brain stimulation for Alzheimer's disease: stimulation parameters and potential mechanisms of action

Y Luo, Y Sun, X Tian, X Zheng, X Wang, W Li… - Frontiers in aging …, 2021 - frontiersin.org
Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by
using internal pulse generators to electrodes in specific target areas of the brain. As a blind …

Deep brain stimulation beyond the clinic: Navigating the future of Parkinson's and Alzheimer's disease therapy

DKL Senevirathne, A Mahboob, K Zhai, P Paul… - Cells, 2023 - mdpi.com
Deep brain stimulation (DBS) is a surgical procedure that uses electrical neuromodulation to
target specific regions of the brain, showing potential in the treatment of neurodegenerative …